Optimus Evidence (Version 1.0) is academic, experimental, and research-support software created by Hazem Ayesh, MD, MPH. References to credentials are for transparency only and do not imply supervision, endorsement, validation, or review. No clinician–user, supervisor–user, or advisory relationship is created.

The software is for exploratory, educational, and analytical purposes. It does not verify, validate, audit, or guarantee the accuracy, correctness, or appropriateness of any statistical method, result, or interpretation. Outputs may contain errors or methodological limitations.

Users are solely responsible for all analytical decisions, interpretations, validations, and reporting derived from the software. The software and its developer assume no responsibility or liability for incorrect, misleading, or incomplete results; misinterpretation or misuse of outputs; downstream consequences in manuscripts, publications, clinical decisions, or policy; or technical errors, bugs, or computational limitations.

Users must independently verify all findings with appropriate statistical expertise before publication or dissemination.

The software is not HIPAA-compliant and must not be used to store or analyze protected health information (PHI) or identifiable patient data. Users are responsible for privacy, data protection, and institutional compliance.

Network meta-analysis methods draw on published work from netmeta, gemtc, BUGSnet, bnma, and CINeMA. These references do not imply endorsement or certification of accuracy. Cite all packages and methods independently.

For complex analyses (large networks, Bayesian models, high heterogeneity, or non-standard assumptions), consult qualified statisticians or methodological experts. The software does not replace expert judgment.

Warranty and liability: THE SOFTWARE IS PROVIDED “AS IS”, WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED. IN NO EVENT SHALL THE DEVELOPER, AUTHORS, OR CONTRIBUTORS BE LIABLE FOR ANY CLAIM OR DAMAGES. BY USING THE SOFTWARE, USERS ASSUME FULL RESPONSIBILITY AND ALL RISKS.